THROMBOSIS AND HEMOSTASIS The kinetics of IIb 3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy
نویسندگان
چکیده
1Cardeza Foundation for Hematologic Research and Department of Medicine, Thomas Jefferson University, Philadelphia, PA; 2Center for Translational Medicine and Department of Medicine, Thomas Jefferson University, Philadelphia, PA; 3Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA; and 4Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA
منابع مشابه
The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.
Two major pathways contribute to Ras-proximate-1-mediated integrin activation in stimulated platelets. Calcium and diacyglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI, RasGRP2) mediates the rapid but reversible activation of integrin αIIbβ3, while the adenosine diphosphate receptor P2Y12, the target for antiplatelet drugs like clopidogrel, facilitates delayed but sustained...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Impaired “outside-in” integrin IIb 3 signaling and thrombus stability in TSSC6-deficient mice
We investigated the role of the hematopoietic-specific tetraspanin superfamily member, TSSC6, in platelet function using wild-type mice and TSSC6-deficient mice. TSSC6 is expressed on the surface of murine platelets and is up-regulated by thrombin stimulation, indicating an intracellular pool of TSSC6. Immunoprecipitation/Western blot studies reveal a constitutive physical association of TSSC6 ...
متن کاملIntelligent platelet inhibitors are on the horizon.
Hemostasis is a tightly regulated physiological sequence of events that maintains vascular integrity and imminent blood loss after vessel injury. Platelets play a critical role in primary hemostasis and in regulation of coagulation. Under physiological conditions, hemostasis and thrombosis are in a fragile equilibrium. Uncontrolled platelet activation leads to intravascular thrombosis and organ...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Continuous signaling via PI3K isoforms and is required for platelet ADP receptor function in dynamic thrombus stabilization
Signaling from collagen and G protein– coupled receptors leads to platelet adhesion and subsequent thrombus formation. Paracrine agonists such as ADP, thromboxane, and Gas6 are required for platelet aggregate formation. We hypothesized that thrombi are intrinsically unstable structures and that their stabilization requires persistent paracrine activity and continuous signaling, maintaining inte...
متن کاملP 149: Effect of Glycoprotein IIb/IIIa Inhibition on Acute Ischemic Stroke Injuries
Ischemic stroke accounts for about 87 percent of all cases. It occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. It is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. We know that most of the injuries after an acute ischemic s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011